Most easily recognized by the spores, which are colorless to yellow, spiny, round, 1-celled, and produced singly at the ends of short filaments. Sometimes phialides of the Acremonium or Gabarnaudia type may also occur. A few species of Mortierella, as well as the human pathogen Histoplasma capsulatum, produce spores resembling those of Sepedonium. Isolated from soil, but most commonly parasitized mushrooms.

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